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Foldamer scaffolds suggest distinct structures are associated with alternative gains-of-function in a preamyloid toxin
An oligoquinoline foldamer library was synthesized and screened for agonism of lipid bilayer catalysed assembly of islet amyloid polypeptide (IAPP). One tetraquinoline, ADM-116, showed exceptional potency not only in this assay, but also in secondary assays measuring lipid bilayer integrity and resc...
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| Pubblicato in: | Chem Commun (Camb) |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4871714/ https://ncbi.nlm.nih.gov/pubmed/27079937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc01248e |
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