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Foldamer scaffolds suggest distinct structures are associated with alternative gains-of-function in a preamyloid toxin

An oligoquinoline foldamer library was synthesized and screened for agonism of lipid bilayer catalysed assembly of islet amyloid polypeptide (IAPP). One tetraquinoline, ADM-116, showed exceptional potency not only in this assay, but also in secondary assays measuring lipid bilayer integrity and resc...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Kumar, Sunil, Birol, Melissa, Miranker, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871714/
https://ncbi.nlm.nih.gov/pubmed/27079937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc01248e
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