A highly conserved region essential for NMD in the Upf2 N-terminal domain

Upf1, Upf2, and Upf3 are the principal regulators of Nonsense-mediated mRNA Decay (NMD), a cytoplasmic surveillance pathway that accelerates the degradation of mRNAs undergoing premature translation termination. These three proteins interact with each other, the ribosome, the translation termination...

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Udgivet i:J Mol Biol
Main Authors: Fourati, Zaineb, Roy, Bijoyita, Millan, Claudia, Coureux, Pierre-Damien, Kervestin, Stéphanie, van Tilbeurgh, Herman, He, Feng, Usón, Isabel, Jacobson, Allan, Graille, Marc
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871600/
https://ncbi.nlm.nih.gov/pubmed/25277656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.09.015
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