JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection

Over half of adults are seropositive for JC polyomavirus (JCV), but rare individuals develop progressive multifocal leukoencephalopathy (PML), a demyelinating JCV infection of the central nervous system. Previously, PML was primarily seen in immunosuppressed patients with AIDS or certain cancers, bu...

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Bibliographic Details
Published in:PLoS One
Main Authors: Wharton, Keith A., Quigley, Catherine, Themeles, Marian, Dunstan, Robert W., Doyle, Kathryn, Cahir-McFarland, Ellen, Wei, Jing, Buko, Alex, Reid, Carl E., Sun, Chao, Carmillo, Paul, Sur, Gargi, Carulli, John P., Mansfield, Keith G., Westmoreland, Susan V., Staugaitis, Susan M., Fox, Robert J., Meier, Werner, Goelz, Susan E.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871437/
https://ncbi.nlm.nih.gov/pubmed/27191595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155897
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