Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women With Polycystic Ovary Syndrome

CONTEXT: Polycystic ovary syndrome (PCOS) is a heritable, complex genetic disease. Animal models suggest that androgen exposure at critical developmental stages contributes to disease pathogenesis. We hypothesized that genetic variation resulting in increased androgen production produces the phenoty...

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Détails bibliographiques
Publié dans:J Clin Endocrinol Metab
Auteurs principaux: Torchen, Laura C., Idkowiak, Jan, Fogel, Naomi R., O'Neil, Donna M., Shackleton, Cedric H. L., Arlt, Wiebke, Dunaif, Andrea
Format: Artigo
Langue:Inglês
Publié: Endocrine Society 2016
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Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870855/
https://ncbi.nlm.nih.gov/pubmed/26990942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2015-3926
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