Design, synthesis, and evaluation of cisplatin-containing EGFR targeting bioconjugates as potential therapeutic agents for brain tumors

The aim of this study was to evaluate four different platinated bioconjugates containing a cisplatin (cis-diamminedichloroplatinum [cis-DDP]) fragment and epidermal growth factor receptor (EGFR)-targeting moieties as potential therapeutic agents for the treatment of brain tumors using a human EGFR-e...

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Bibliographische Detailangaben
Veröffentlicht in:Onco Targets Ther
Hauptverfasser: Barth, Rolf F, Wu, Gong, Meisen, W Hans, Nakkula, Robin J, Yang, Weilian, Huo, Tianyao, Kellough, David A, Kaumaya, Pravin, Turro, Claudia, Agius, Lawrence M, Kaur, Balveen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2016
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869632/
https://ncbi.nlm.nih.gov/pubmed/27274273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S99242
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