Functional evaluation of TERT-CLPTM1L genetic variants associated with susceptibility of papillary thyroid carcinoma

TERT is the catalytic subunit of telomerase which plays an essential part in cellular immortality by maintaining telomere integrity. TERT is commonly over-expressed in human malignancies, indicating its key role in cell transformation. The chromosome 5p15.33 TERT-CLPTM1L region has been associated w...

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Udgivet i:Sci Rep
Main Authors: Ge, Minghua, Shi, Meng, An, Changming, Yang, Wenjun, Nie, Xilin, Zhang, Jian, Lv, Zheng, Li, Jinliang, Zhou, Liqing, Du, Zhongli, Yang, Ming
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869017/
https://ncbi.nlm.nih.gov/pubmed/27185198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26037
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