MiR-let-7a inhibits cell proliferation, migration, and invasion by down-regulating PKM2 in gastric cancer

In contrast to normal differentiated cells that depend on aerobicoxidation for energy production, cancer cells use aerobic glycolysis as the main source (Warburg's effect). The M2 splice isoform of pyruvate kinase (PKM2) is the key regulator for the aerobic glycolysis, high expression of PKM2 c...

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Vydáno v:Oncotarget
Hlavní autoři: Tang, Ran, Yang, Chao, Ma, Xiang, Wang, Younan, Luo, Dakui, Huang, Chi, Xu, Zekuan, Liu, Ping, Yang, Li
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868734/
https://ncbi.nlm.nih.gov/pubmed/26745603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6821
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