Expression of the FGFR2 mesenchymal splicing variant in epithelial cells drives epithelial-mesenchymal transition

The FGFRs are receptor tyrosine kinases expressed by tissue-specific alternative splicing in epithelial IIIb or mesenchymal IIIc isoforms. Deregulation of FGF/FGFR signaling unbalances the epithelial-stromal homeostasis and may lead to cancer development. In the epithelial-context, while FGFR2b/KGFR...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ranieri, Danilo, Rosato, Benedetta, Nanni, Monica, Magenta, Alessandra, Belleudi, Francesca, Torrisi, Maria Rosaria
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868697/
https://ncbi.nlm.nih.gov/pubmed/26713601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6706
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