Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgen-independent prostate cancer cells to DNA damage

Patients with hormone-resistant prostate cancer (PCa) have higher biochemical failure rates following radiation therapy (RT). Cyclin D1 deregulated expression in PCa is associated with a more aggressive disease: however its role in radioresistance has not been determined. Cyclin D1 levels in the and...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Marampon, Francesco, Gravina, Giovanni, Ju, Xiaoming, Vetuschi, Antonella, Sferra, Roberta, Casimiro, Mathew C., Pompili, Simona, Festuccia, Claudio, Colapietro, Alessandro, Gaudio, Eugenio, Di Cesare, Ernesto, Tombolini, Vincenzo, Pestell, Richard G.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868693/
https://ncbi.nlm.nih.gov/pubmed/26689991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6579
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