Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone

Pathogenic factors associated with aging, such as oxidative stress and hormone depletion converge on mitochondria and impair their function via opening of the mitochondrial permeability transition pore (MPTP). The MPTP is a large non-selective pore regulated by cyclophilin D (CypD) that disrupts mit...

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Udgivet i:PLoS One
Main Authors: Shum, Laura C., White, Noelle S, Nadtochiy, Sergiy M., Bentley, Karen L. de Mesy, Brookes, Paul S, Jonason, Jennifer H., Eliseev, Roman A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868300/
https://ncbi.nlm.nih.gov/pubmed/27183225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155709
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