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Hyperpolarized [(13)C]ketobutyrate, a molecular analog of pyruvate with modified specificity for LDH isoforms
PURPOSE: The purpose of this study was to investigate (13)C hyperpolarization of α-ketobutyrate (αKB), an endogenous molecular analog of pyruvate, and its in vivo enzymatic conversion via lactate dehydrogenase (LDH), using localized MR spectroscopy. METHODS: Hyperpolarized (HP) (13)C MR experiments...
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| Published in: | Magn Reson Med |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4868134/ https://ncbi.nlm.nih.gov/pubmed/26059096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.25716 |
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