Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold

[Image: see text] A series of allosteric kidney-type glutaminase (GLS) inhibitors were designed and synthesized using 1,4-di(5-amino-1,3,4-thiadiazol-2-yl)butane as a core scaffold. A variety of modified phenylacetyl groups were incorporated into the 5-amino group of the two thiadiazole rings in an...

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Publié dans:ACS Med Chem Lett
Auteurs principaux: Zimmermann, Sarah C., Wolf, Emily F., Luu, Andrew, Thomas, Ajit G., Stathis, Marigo, Poore, Brad, Nguyen, Christopher, Le, Anne, Rojas, Camilo, Slusher, Barbara S., Tsukamoto, Takashi
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2016
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868099/
https://ncbi.nlm.nih.gov/pubmed/27200176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00060
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