Humoral Immune Response against Nontargeted Tumor Antigens after Treatment with Sipuleucel-T and Its Association with Improved Clinical Outcome

PURPOSE: Antitumor activity of cancer immunotherapies may elicit immune responses to nontargeted (secondary) tumor antigens, or antigen spread. We evaluated humoral antigen spread after treatment with sipuleucel-T, an immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resi...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: GuhaThakurta, Debraj, Sheikh, Nadeem A., Fan, Li-Qun, Kandadi, Harini, Meagher, T. Craig, Hall, Simon J., Kantoff, Philip W., Higano, Celestia S., Small, Eric J., Gardner, Thomas A., Bailey, Kate, Vu, Tuyen, DeVries, Todd, Whitmore, James B., Frohlich, Mark W., Trager, James B., Drake, Charles G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868054/
https://ncbi.nlm.nih.gov/pubmed/25649018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2334
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