Frequencies of CYP2C9 polymorphisms in North Indian population and their association with drug levels in children on phenytoin monotherapy

BACKGROUND: Phenytoin, mainly metabolized by cytochrome P450 enzyme system, has a narrow therapeutic index and may have adverse effects due to inter-individual variation in the dose requirement and genetic polymorphisms. This cross-sectional study was done to study the prevalence of cytochrome P450...

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Vydáno v:BMC Pediatr
Hlavní autoři: Chaudhary, Nagendra, Kabra, Madhulika, Gulati, Sheffali, Gupta, Yogendra Kumar, Pandey, Ravindra Mohan, Bhatia, Bal Dev
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868001/
https://ncbi.nlm.nih.gov/pubmed/27179628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12887-016-0603-0
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