BN‐9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance‐forming antinociception in mice

BACKGROUND AND PURPOSE: Neuropeptide FF (NPFF) behaves as an endogenous opioid‐modulating peptide. In the present study, the opioid and NPFF pharmacophore‐containing chimeric peptide BN‐9 was synthesized and pharmacologically characterized. EXPERIMENTAL APPROACH: Agonist activities of BN‐9 at opioid...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Li, Ning, Han, Zheng‐lan, Wang, Zi‐long, Xing, Yan‐hong, Sun, Yu‐long, Li, Xu‐hui, Song, Jing‐jing, Zhang, Ting, Zhang, Run, Zhang, Meng‐na, Xu, Biao, Fang, Quan, Wang, Rui
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867745/
https://ncbi.nlm.nih.gov/pubmed/27018797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13489
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