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Design, Synthesis, and Evaluation of Donepezil-Like Compounds as AChE and BACE-1 Inhibitors

[Image: see text] An ecofriendly synthetic pathway for the synthesis of donepezil precursors is described. Alternative energy sources were used for the total synthesis in order to improve yields, regioselectively, and rate of each synthetic step and to reduce the coproduction of waste at the same ti...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Costanzo, Paola, Cariati, Luca, Desiderio, Doriana, Sgammato, Roberta, Lamberti, Anna, Arcone, Rosaria, Salerno, Raffaele, Nardi, Monica, Masullo, Mariorosario, Oliverio, Manuela
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867475/
https://ncbi.nlm.nih.gov/pubmed/27190595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00483
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