Aging-related impairment of urine-concentrating mechanisms correlates with dysregulation of adrenocortical angiotensin type 1 receptors in male Fischer rats

To investigate age-associated impairments in fluid homeostasis, 4-mo (young) and 32-mo (old) Fischer 344/BN male rats were studied before and after a dietary sodium load. Transferring young rats from a low-sodium (LS) to a high-sodium (HS) diet increased water intake and urine volume by 1.9- and 3.0...

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Pubblicato in:Am J Physiol Regul Integr Comp Physiol
Autori principali: Ji, Hong, Zheng, Wei, Wu, Xie, Speth, Robert C., Verbalis, Joseph G., Stein, Lauren M., Yosten, Gina L. C., Samson, Willis K., Sandberg, Kathryn
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
Soggetti:
Fluid and Electrolyte Homeostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867372/
https://ncbi.nlm.nih.gov/pubmed/26702152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00131.2015
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