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Modulating non-native aggregation and electrostatic protein–protein interactions with computationally designed single-point mutations
Non-native protein aggregation is a ubiquitous challenge in the production, storage and administration of protein-based biotherapeutics. This study focuses on altering electrostatic protein–protein interactions as a strategy to modulate aggregation propensity in terms of temperature-dependent aggreg...
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| Publicado no: | Protein Eng Des Sel |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4867096/ https://ncbi.nlm.nih.gov/pubmed/27160179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzw010 |
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