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Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci

LINE-1 (L1) retrotransposons represent approximately one sixth of the human genome, but only the human-specific L1HS-Ta subfamily acts as an endogenous mutagen in modern humans, reshaping both somatic and germline genomes. Due to their high levels of sequence identity and the existence of many polym...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Philippe, Claude, Vargas-Landin, Dulce B, Doucet, Aurélien J, van Essen, Dominic, Vera-Otarola, Jorge, Kuciak, Monika, Corbin, Antoine, Nigumann, Pilvi, Cristofari, Gaël
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866827/
https://ncbi.nlm.nih.gov/pubmed/27016617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13926
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