Development of micro-fibrous solid dispersions of poorly water-soluble drugs in sucrose using temperature-controlled centrifugal spinning

Solid dispersion technology represents a successful approach to addressing the bioavailability issues caused by the low aqueous solubility of many Biopharmaceutics Classification System (BCS) Class II drugs. In this study, the use of high-yield manufacture of fiber-based dispersion is explored as an...

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Detalhes bibliográficos
Publicado no:Eur J Pharm Biopharm
Main Authors: Marano, Stefania, Barker, Susan Anne, Raimi-Abraham, Bahijja Tolulope, Missaghi, Shahrzad, Rajabi-Siahboomi, Ali, Craig, Duncan Q.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866555/
https://ncbi.nlm.nih.gov/pubmed/27012901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejpb.2016.03.021
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