Tumour resistance in induced pluripotent stem cells derived from naked mole-rats

The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent st...

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Udgivet i:Nat Commun
Main Authors: Miyawaki, Shingo, Kawamura, Yoshimi, Oiwa, Yuki, Shimizu, Atsushi, Hachiya, Tsuyoshi, Bono, Hidemasa, Koya, Ikuko, Okada, Yohei, Kimura, Tokuhiro, Tsuchiya, Yoshihiro, Suzuki, Sadafumi, Onishi, Nobuyuki, Kuzumaki, Naoko, Matsuzaki, Yumi, Narita, Minoru, Ikeda, Eiji, Okanoya, Kazuo, Seino, Ken-ichiro, Saya, Hideyuki, Okano, Hideyuki, Miura, Kyoko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866046/
https://ncbi.nlm.nih.gov/pubmed/27161380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11471
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