The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes

Continuous cycles of nucleocytoplasmic transport require disassembly of transport receptor/Ran-GTP complexes in the cytoplasm. A basic disassembly mechanism in all eukaryotes depends on soluble RanGAP and RanBP1. In vertebrates, a significant fraction of RanGAP1 stably interacts with the nucleoporin...

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Vydáno v:Nat Commun
Hlavní autoři: Ritterhoff, Tobias, Das, Hrishikesh, Hofhaus, Götz, Schröder, Rasmus R., Flotho, Annette, Melchior, Frauke
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866044/
https://ncbi.nlm.nih.gov/pubmed/27160050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11482
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