Peroxisome proliferator-activated receptor-gamma dependent pathway reduces the phosphorylation of dynamin-related protein 1 and ameliorates hippocampal injury induced by global ischemia in rats

BACKGROUND: Dynamin-related protein 1 (Drp1) is a mitochondrial fission protein that, upon phosphorylation at serine 616 (p-Drp1(Ser616)), plays a pivotal role in neuronal death after ischemia. In the present study, we hypothesized that peroxisome proliferator-activated receptor-gamma (PPARγ)-depend...

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Vydáno v:J Biomed Sci
Hlavní autoři: Chuang, Yao-Chung, Lin, Tsu-Kung, Yang, Ding-I, Yang, Jenq-Lin, Liou, Chia-Wei, Chen, Shang-Der
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865999/
https://ncbi.nlm.nih.gov/pubmed/27175924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-016-0262-3
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