The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study

BACKGROUND: Germline mutations in BRCA1 and BRCA2 increase the susceptibility to develop breast and ovarian cancers as well as increase the risk of some other cancers. Primary objective was to estimate the risk of leukaemia in BRCA1 and BRCA2 mutation carriers. METHODS: We followed 7243 women with a...

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Vydáno v:Br J Cancer
Hlavní autoři: Iqbal, Javaid, Nussenzweig, Andre, Lubinski, Jan, Byrski, Tomasz, Eisen, Andrea, Bordeleau, Louise, Tung, Nadine M, Manoukian, Siranoush, Phelan, Catherine M, Sun, Ping, Narod, Steven A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
Genetics and Genomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865972/
https://ncbi.nlm.nih.gov/pubmed/26986251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.58
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