Activated α(2)-Macroglobulin Regulates Transcriptional Activation of c-MYC Target Genes through Cell Surface GRP78 Protein

Activated α(2)-macroglobulin (α(2)M*) signals predominantly through cell surface GRP78 (CS-GRP78) to promote proliferation and survival of cancer cells; however, the molecular mechanism remains obscure. c-MYC is an essential transcriptional regulator that controls cell proliferation. We hypothesize...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Gopal, Udhayakumar, Gonzalez-Gronow, Mario, Pizzo, Salvatore Vincent
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865935/
https://ncbi.nlm.nih.gov/pubmed/27002159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708131
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