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ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ.

Tyrosine hydroxylase (TH) is phosphorylated at four sites in situ and in vivo, and the protein kinases that phosphorylate three of these sites (Ser8,Ser19,Ser40) have been identified. In intact cells, the phosphorylation of the fourth site (Ser31) is increased in response to phorbol esters or nerve...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Haycock, J W, Ahn, N G, Cobb, M H, Krebs, E G
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48658/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1347949/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.6.2365
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