A gene encoding a putative tyrosine phosphatase suppresses lethality of an N-end rule-dependent mutant.
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. In the yeast Saccharomyces cerevisiae, mutational inactivation of the N-end rule pathway is neither lethal nor phenotypically conspicuous. We have used a "synthetic lethal" screen to isolate a mutant...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48656/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1549598/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.6.2355 |
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