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The Grp170 nucleotide exchange factor executes a key role during ERAD of cellular misfolded clients
When a protein misfolds in the endoplasmic reticulum (ER), it retrotranslocates to the cytosol and is degraded by the proteasome via a pathway called ER-associated degradation (ERAD). To initiate ERAD, ADP-BiP is often recruited to the misfolded client, rendering it soluble and translocation compete...
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| Publicado en: | Mol Biol Cell |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Cell Biology
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4865321/ https://ncbi.nlm.nih.gov/pubmed/27030672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-01-0033 |
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