A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans

Genome-wide association studies have implicated the CHRNA5-CHRNA3-CHRNB4 gene cluster in risk for heavy smoking and several smoking-related disorders. The heavy smoking risk allele might reduce the aversive effects of nicotine, but this hypothesis has not been tested in humans. We evaluated the effe...

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Publicat a:Neuropsychopharmacology
Autors principals: Jensen, Kevin P, DeVito, Elise E, Herman, Aryeh I, Valentine, Gerald W, Gelernter, Joel, Sofuoglu, Mehmet
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864657/
https://ncbi.nlm.nih.gov/pubmed/25948103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.131
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