Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation

Although alcohol consumption is linked to increased aggression, its neural correlates have not directly been studied in humans so far. Based on a comprehensive neurobiological model of alcohol-induced aggression, we hypothesized that alcohol-induced aggression would go along with increased amygdala...

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Publicado no:Neuropsychopharmacology
Main Authors: Gan, Gabriela, Sterzer, Philipp, Marxen, Michael, Zimmermann, Ulrich S, Smolka, Michael N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864624/
https://ncbi.nlm.nih.gov/pubmed/25971590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.141
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spelling pubmed-48646242016-12-01 Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation Gan, Gabriela Sterzer, Philipp Marxen, Michael Zimmermann, Ulrich S Smolka, Michael N Neuropsychopharmacology Original Article Although alcohol consumption is linked to increased aggression, its neural correlates have not directly been studied in humans so far. Based on a comprehensive neurobiological model of alcohol-induced aggression, we hypothesized that alcohol-induced aggression would go along with increased amygdala and ventral striatum reactivity and impaired functioning of the prefrontal cortex (PFC) under alcohol. We measured neural and behavioral correlates of alcohol-induced aggression in a provoking vs non-provoking condition with a variant of the Taylor aggression paradigm (TAP) allowing to differentiate between reactive (provoked) and proactive (unprovoked) aggression. In a placebo-controlled cross-over design with moderate alcohol intoxication (~0.6 g/kg), 35 young healthy adults performed the TAP during functional magnetic resonance imaging (fMRI). Analyses revealed that provoking vs non-provoking conditions and alcohol vs placebo increased aggression and decreased brain responses in the anterior cingulate cortex/dorso-medial PFC (provoking<non-provoking) and the ventral striatum (alcohol<placebo) across our healthy sample. Interestingly, alcohol specifically increased proactive (unprovoked) but not reactive (provoked) aggression (alcohol × provocation interaction). However, investigation of inter-individual differences revealed (1) that pronounced alcohol-induced proactive aggression was linked to higher levels of aggression under placebo, and (2) that pronounced alcohol-induced reactive aggression was related to increased amygdala and ventral striatum reactivity under alcohol, providing evidence for their role in human alcohol-induced reactive aggression. Our findings suggest that in healthy young adults a liability for alcohol-induced aggression in a non-provoking context might depend on overall high levels of aggression, but on alcohol-induced increased striatal and amygdala reactivity when triggered by provocation. Nature Publishing Group 2015-12 2015-06-24 /pmc/articles/PMC4864624/ /pubmed/25971590 http://dx.doi.org/10.1038/npp.2015.141 Text en Copyright © 2015 American College of Neuropsychopharmacology
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Original Article
spellingShingle Original Article
Gan, Gabriela
Sterzer, Philipp
Marxen, Michael
Zimmermann, Ulrich S
Smolka, Michael N
Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation
description Although alcohol consumption is linked to increased aggression, its neural correlates have not directly been studied in humans so far. Based on a comprehensive neurobiological model of alcohol-induced aggression, we hypothesized that alcohol-induced aggression would go along with increased amygdala and ventral striatum reactivity and impaired functioning of the prefrontal cortex (PFC) under alcohol. We measured neural and behavioral correlates of alcohol-induced aggression in a provoking vs non-provoking condition with a variant of the Taylor aggression paradigm (TAP) allowing to differentiate between reactive (provoked) and proactive (unprovoked) aggression. In a placebo-controlled cross-over design with moderate alcohol intoxication (~0.6 g/kg), 35 young healthy adults performed the TAP during functional magnetic resonance imaging (fMRI). Analyses revealed that provoking vs non-provoking conditions and alcohol vs placebo increased aggression and decreased brain responses in the anterior cingulate cortex/dorso-medial PFC (provoking<non-provoking) and the ventral striatum (alcohol<placebo) across our healthy sample. Interestingly, alcohol specifically increased proactive (unprovoked) but not reactive (provoked) aggression (alcohol × provocation interaction). However, investigation of inter-individual differences revealed (1) that pronounced alcohol-induced proactive aggression was linked to higher levels of aggression under placebo, and (2) that pronounced alcohol-induced reactive aggression was related to increased amygdala and ventral striatum reactivity under alcohol, providing evidence for their role in human alcohol-induced reactive aggression. Our findings suggest that in healthy young adults a liability for alcohol-induced aggression in a non-provoking context might depend on overall high levels of aggression, but on alcohol-induced increased striatal and amygdala reactivity when triggered by provocation.
author Gan, Gabriela
Sterzer, Philipp
Marxen, Michael
Zimmermann, Ulrich S
Smolka, Michael N
author_facet Gan, Gabriela
Sterzer, Philipp
Marxen, Michael
Zimmermann, Ulrich S
Smolka, Michael N
author_sort Gan, Gabriela
title Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation
title_short Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation
title_full Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation
title_fullStr Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation
title_full_unstemmed Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation
title_sort neural and behavioral correlates of alcohol-induced aggression under provocation
publisher Nature Publishing Group
container_title Neuropsychopharmacology
publishDate 2015
url https://ncbi.nlm.nih.gov/pmc/articles/PMC4864624/
https://ncbi.nlm.nih.gov/pubmed/25971590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.141
_version_ 1815340246491987968

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