ALPK1 phosphorylates myosin IIA modulating TNF-α trafficking in gout flares

Gout is characterized by the monosodium urate monohydrate (MSU)-induced arthritis. Alpha kinase-1 (ALPK1) has shown to be associated with MSU-induced inflammation and gout. Here, we used bioinformatics, proteomics, cell models, and twenty in vitro human assays to clarify some of its role in the infl...

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Publicat a:Sci Rep
Autors principals: Lee, Chi-Pin, Chiang, Shang-Lun, Ko, Albert Min-Shan, Liu, Yu-Fan, Ma, Che, Lu, Chi-Yu, Huang, Chung-Ming, Chang, Jan-Gowth, Kuo, Tzer-Min, Chen, Chia-Lin, Tsai, Eing-Mei, Ko, Ying-Chin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864424/
https://ncbi.nlm.nih.gov/pubmed/27169898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25740
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