p62/SQSTM1 but not LC3 is accumulated in sarcopenic muscle of mice

AIM: We investigated the pathway of autophagy signaling linked to sarcopenia of mice. METHODS: Young adult (3‐month) and aged (24‐ month) C57BL/6J mice were used. Using real‐time PCR, Western blotting, and immunohistochemical microscopy, we evaluated the amounts of p62/SQSTM1, LC3, and Beclin‐1 in t...

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Bibliographic Details
Published in:J Cachexia Sarcopenia Muscle
Main Authors: Sakuma, Kunihiro, Kinoshita, Masakazu, Ito, Yoshinori, Aizawa, Miki, Aoi, Wataru, Yamaguchi, Akihiko
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2015
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864138/
https://ncbi.nlm.nih.gov/pubmed/27493873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12045
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