E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes

BACKGROUND: Estrogen deficiency is closely related to the development of menopausal arthritis. Estrogen replacement therapy (ERT) shows a protective effect against the osteoarthritis. However, the underlying mechanism of this protective effect is unknown. This study aimed to determine the role of mi...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Liang, Yujie, Duan, Li, Xiong, Jianyi, Zhu, Weiming, Liu, Qisong, Wang, Daming, Liu, Wei, Li, Zigang, Wang, Daping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863330/
https://ncbi.nlm.nih.gov/pubmed/27165343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-0997-y
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