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Network Analysis of Sequence-Function Relationships and Exploration of Sequence Space of TEM β-Lactamases

The Lactamase Engineering Database (www.LacED.uni-stuttgart.de) was developed to facilitate the classification and analysis of TEM β-lactamases. The current version contains 474 TEM variants. Two hundred fifty-nine variants form a large scale-free network of highly connected point mutants. The netwo...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Zeil, Catharina, Widmann, Michael, Fademrecht, Silvia, Vogel, Constantin, Pleiss, Jürgen
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862526/
https://ncbi.nlm.nih.gov/pubmed/26883706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02930-15
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