Local corticosterone activation by 11β-hydroxysteroid dehydrogenase 1 in keratinocytes: the role in narrow-band UVB-induced dermatitis

Keratinocytes are known to synthesize cortisol through activation of the enzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). To confirm the function of 11β-HSD1 in keratinocytes during inflammation in vivo, we created keratinocyte-specific-11β-HSD1 knockout mice (K5-Hsd11b1-KO mice) and analyzed t...

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Veröffentlicht in:Dermatoendocrinol
Hauptverfasser: Itoi-Ochi, Saori, Terao, Mika, Murota, Hiroyuki, Katayama, Ichiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862380/
https://ncbi.nlm.nih.gov/pubmed/27195053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19381980.2015.1119958
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