The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands

In this article we report a combined experimental and computational study concerning the effects of deuteration on the binding of histamine and two other histaminergic agonists to (3)H-tiotidine-labeled histamine H2 receptor in neonatal rat astrocytes. Binding affinities were measured by displacing...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kržan, Mojca, Vianello, Robert, Maršavelski, Aleksandra, Repič, Matej, Zakšek, Maja, Kotnik, Kristina, Fijan, Estera, Mavri, Janez
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861267/
https://ncbi.nlm.nih.gov/pubmed/27159606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154002
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