Reductive carboxylation supports redox homeostasis during anchorage-independent growth

Epithelial cells receive growth and survival stimuli through their attachment to an extracellular matrix (ECM)(1). Overcoming the addiction to ECM-induced signals is required for anchorage-independent growth, a property of most malignant cells(2). Detachment from ECM is associated with enhanced reac...

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Publicado en:Nature
Main Authors: Jiang, Lei, Shestov, Alexander A., Swain, Pamela, Yang, Chendong, Parker, Seth J., Wang, Qiong A., Terada, Lance S., Adams, Nicholas D., McCabe, Michael T., Pietrak, Beth, Schmidt, Stan, Metallo, Christian M., Dranka, Brian P., Schwartz, Benjamin, DeBerardinis, Ralph J.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860952/
https://ncbi.nlm.nih.gov/pubmed/27049945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17393
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