EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway

Transforming growth factor-β (TGF-β) induces apoptosis in many types of cancer cells and acts as a tumor suppressor. We performed a functional analysis of TGF-β signaling to identify a molecular mechanism that regulated survival in small cell lung cancer cells. Here, we found low expression of TGF-β...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Discov
Egile Nagusiak: Murai, Fumihiko, Koinuma, Daizo, Shinozaki-Ushiku, Aya, Fukayama, Masashi, Miyaozono, Kohei, Ehata, Shogo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860843/
https://ncbi.nlm.nih.gov/pubmed/27462425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.26
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