Increased CD271 expression by the NF-kB pathway promotes melanoma cell survival and drives acquired resistance to BRAF inhibitor vemurafenib

Specific BRAFV600E inhibitors (BRAFi) are highly effective in the treatment of melanoma. However, acquired drug resistances invariably develop after the initial response. Therefore, the identification of new mechanisms of acquired resistance gives important clues towards the development of therapies...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Lehraiki, Abdelali, Cerezo, Michael, Rouaud, Florian, Abbe, Patricia, Allegra, Marilyne, Kluza, Jerome, Marchetti, Philippe, Imbert, Veronique, Cheli, Yann, Bertolotto, Corine, Ballotti, Robert, Rocchi, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860830/
https://ncbi.nlm.nih.gov/pubmed/27462428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.30
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