Increased CD271 expression by the NF-kB pathway promotes melanoma cell survival and drives acquired resistance to BRAF inhibitor vemurafenib

Specific BRAFV600E inhibitors (BRAFi) are highly effective in the treatment of melanoma. However, acquired drug resistances invariably develop after the initial response. Therefore, the identification of new mechanisms of acquired resistance gives important clues towards the development of therapies...

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Gepubliceerd in:Cell Discov
Hoofdauteurs: Lehraiki, Abdelali, Cerezo, Michael, Rouaud, Florian, Abbe, Patricia, Allegra, Marilyne, Kluza, Jerome, Marchetti, Philippe, Imbert, Veronique, Cheli, Yann, Bertolotto, Corine, Ballotti, Robert, Rocchi, Stéphane
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860830/
https://ncbi.nlm.nih.gov/pubmed/27462428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.30
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