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N-hypermannose glycosylation disruption enhances recombinant protein production by regulating secretory pathway and cell wall integrity in Saccharomyces cerevisiae

Saccharomyces cerevisiae is a robust host for heterologous protein expression. The efficient expression of cellulases in S. cerevisiae is important for the consolidated bioprocess that directly converts lignocellulose into valuable products. However, heterologous proteins are often N-hyperglycosylat...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tang, Hongting, Wang, Shenghuan, Wang, Jiajing, Song, Meihui, Xu, Mengyang, Zhang, Mengying, Shen, Yu, Hou, Jin, Bao, Xiaoming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860636/
https://ncbi.nlm.nih.gov/pubmed/27156860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25654
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