Rifaximin Improves Clostridium difficile Toxin A-Induced Toxicity in Caco-2 Cells by the PXR-Dependent TLR4/MyD88/NF-κB Pathway

Background: Clostridium difficile infections (CDIs) caused by Clostridium difficile toxin A (TcdA) lead to severe ulceration, inflammation and bleeding of the colon, and are difficult to treat. Aim: The study aimed to evaluate the effect of rifaximin on TcdA-induced apoptosis in intestinal epithelia...

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Podrobná bibliografie
Vydáno v:Front Pharmacol
Hlavní autoři: Esposito, Giuseppe, Nobile, Nicola, Gigli, Stefano, Seguella, Luisa, Pesce, Marcella, d’Alessandro, Alessandra, Bruzzese, Eugenia, Capoccia, Elena, Steardo, Luca, Cuomo, Rosario, Sarnelli, Giovanni
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860461/
https://ncbi.nlm.nih.gov/pubmed/27242527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00120
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