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Endogenous Glucagon-like peptide-1 suppresses high-fat food intake by reducing synaptic drive onto mesolimbic dopamine neurons

Glucagon-like peptide-1 (GLP-1) and its analogs act as appetite suppressants and have been proven to be clinically efficacious in reducing body weight in obese individuals. Central GLP-1 is expressed in a small population of brainstem cells located in the nucleus tractus solitarius (NTS), which proj...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Wang, Xue-Feng, Liu, Jing-Jing, Xia, Julia, Liu, Ji, Mirabella, Vincent, Pang, Zhiping P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860285/
https://ncbi.nlm.nih.gov/pubmed/26212334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.062
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