Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer’s disease

Brain activities of the mitochondrial enzyme α-ketoglutarate dehydrogenase complex (KGDHC) are reduced in Alzheimer’s disease and other age-related neurodegenerative disorders. The goal of the present study was to test the consequences of mild impairment of KGDHC on the structure, protein signaling...

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Detalhes bibliográficos
Publicado no:Neurochem Int
Main Authors: Banerjee, Kalpita, Munshi, Soumyabrata, Xu, Hui, Frank, David E., Chen, Huan-Lian, Chu, Charleen T., Yang, Jiwon, Cho, Sunghee, Kagan, Valerian E., Denton, Travis T., Tyurina, Yulia Yurjevna, Jiang, Jian Fei, Gibson, Gary E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860123/
https://ncbi.nlm.nih.gov/pubmed/26923918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2016.02.011
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