Endothelial AMPK Activation Induces Mitochondrial Biogenesis and Stress Adaptation via eNOS-Dependent mTORC1 Signaling

Metabolic stress sensors like AMP-activated protein kinase (AMPK) are known to confer stress adaptation and promote longevity in lower organisms. This study demonstrates that activating the metabolic stress sensor AMP-activated protein kinase (AMPK) in endothelial cells helps maintain normal cellula...

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Bibliographic Details
Published in:Nitric Oxide
Main Authors: Li, Chunying, Reif, Michaella M, Craige, Siobhan, Kant, Shashi, Keaney, John F.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860108/
https://ncbi.nlm.nih.gov/pubmed/26989010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2016.03.003
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