Galectin-1 mediates TGF-β-induced transformation from normal fibroblasts into carcinoma-associated fibroblasts and promotes tumor progression in gastric cancer

Rcinoma-associated fibroblasts (CAFs) are a major constituent of the tumor microenvironment. Cancer cells can induce the transformation from normal fibroblasts (NFs) into CAFs, reciprocally, CAFs promote tumor invasion and proliferation. TGF-β has been the mostly accepted factor to fuel NFs transfor...

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Udgivet i:Am J Transl Res
Main Authors: Zheng, Lingyan, Xu, Cong, Guan, Zhonghai, Su, Xingyun, Xu, Zhenzhen, Cao, Jiang, Teng, Lisong
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859895/
https://ncbi.nlm.nih.gov/pubmed/27186290
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