The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development

The Apelin receptor (Aplnr) is essential for heart development, controlling the early migration of cardiac progenitors. Here we demonstrate that in zebrafish Aplnr modulates Nodal/TGFβ signaling, a key pathway essential for mesendoderm induction and migration. Loss of Aplnr function leads to a reduc...

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Udgivet i:eLife
Main Authors: Deshwar, Ashish R, Chng, Serene C, Ho, Lena, Reversade, Bruno, Scott, Ian C
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Developmental Biology and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859801/
https://ncbi.nlm.nih.gov/pubmed/27077952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13758
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