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The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development
The Apelin receptor (Aplnr) is essential for heart development, controlling the early migration of cardiac progenitors. Here we demonstrate that in zebrafish Aplnr modulates Nodal/TGFβ signaling, a key pathway essential for mesendoderm induction and migration. Loss of Aplnr function leads to a reduc...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4859801/ https://ncbi.nlm.nih.gov/pubmed/27077952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13758 |
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