The molecular basis for ANE syndrome revealed by the large ribosomal subunit processome interactome

ANE syndrome is a ribosomopathy caused by a mutation in an RNA recognition motif of RBM28, a nucleolar protein conserved to yeast (Nop4). While patients with ANE syndrome have fewer mature ribosomes, it is unclear how this mutation disrupts ribosome assembly. Here we use yeast as a model system and...

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Udgivet i:eLife
Main Authors: McCann, Kathleen L, Teramoto, Takamasa, Zhang, Jun, Tanaka Hall, Traci M, Baserga, Susan J
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Biophysics and Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859800/
https://ncbi.nlm.nih.gov/pubmed/27077951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16381
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