p38β Mitogen-Activated Protein Kinase Modulates Its Own Basal Activity by Autophosphorylation of the Activating Residue Thr180 and the Inhibitory Residues Thr241 and Ser261

Many enzymes are self-regulated and can either inhibit or enhance their own catalytic activity. Enzymes that do both are extremely rare. Many protein kinases autoactivate by autophosphorylating specific sites at their activation loop and are inactivated by phosphatases. Although mitogen-activated pr...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Beenstock, Jonah, Melamed, Dganit, Mooshayef, Navit, Mordechay, Dafna, Garfinkel, Benjamin P., Ahn, Natalie G., Admon, Arie, Engelberg, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859693/
https://ncbi.nlm.nih.gov/pubmed/26976637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01105-15
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