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Methylation-mediated loss of SFRP2 enhances melanoma cell invasion via Wnt signaling
Wnt signaling plays an essential role in the initiation and progression of melanoma tumors. The Secreted Frizzled Related Proteins (SFRPs) are a family of proteins that suppress Wnt signaling. The methylation of SFRPs reduces their activity, and hence augments Wnt signaling. However, whether the met...
Gespeichert in:
| Veröffentlicht in: | Am J Transl Res |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
e-Century Publishing Corporation
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4859635/ https://ncbi.nlm.nih.gov/pubmed/27186276 |
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