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The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB(2), TRPV1, TRPA1 and yet unidentified receptor targets
BACKGROUND: In rheumatoid arthritis (RA), synovial fibroblasts (SF) secrete large amounts of IL-6, IL-8 and matrix metalloproteinases (MMPs) which are crucial for cartilage destruction. RASFs are sensitive to the action of cannabinoids and they not only express cannabinoid receptors type I and II (C...
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| Publicado no: | J Inflamm (Lond) |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4858820/ https://ncbi.nlm.nih.gov/pubmed/27158245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12950-016-0114-7 |
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